Protein Details: Potassium voltage-gated channel subfamily E member 1

Protein ID

ICDB_Pro_0419

Protein Name

Potassium voltage-gated channel subfamily E member 1

Gene Name

Kcne1

Organism

Mus musculus (Mouse)

Length

129 amino acids

AlphaFoldDB

AF-P23299-F1-model_v4.pdb

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr)

Sequence

MSLPNSTTVLPFLARLWQETAEQGGNVSGLARKSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKAVFQARVLESFRACYVIENQAAVEQPATHLPELKPLS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Restrictively localized in the apical membrane portion of epithelial cells.

DOI ID

10.1002/j.1460-2075.1991.tb07829.x; 10.1016/0014-5793(92)81240-m; 10.1126/science.1112014; 10.1038/384078a0

RefSeq

NP_032450.1; XP_006523004.1